Local centres constitute the first level of the network. Present in various European and non-European countries, they are represented by one or more Reporting physicians who play a key role in enrolling eligible patients.
Reporting physicians collect data using a standardised Case Report Form (CRF) and send it immediately to their own National coordinators for a preliminary check.
CRFs are subsequently transferred to the Central Registry in Milan, Italy, where they are further controlled for missing information and inconsistencies.
Pregnancies reporting descriptions of congenital abnormalities are transmitted to the Outcome Classification Commission for definitive classification of major malformations.